{ "nid": "96", "details": "\x3cspan class=\"title\"\x3eNerveWorks: Pay Attention\x3c/span\x3e\x3cbr/\x3e\n\x3cspan class=\"description\"\x3eIn this lab you study how the catecholamine norepinephrine modulates the firing properties of hippocampal CA1 neurons (\x3ci\x3eMadison and Nicoll, 1986\x3c/i\x3e). In the last part of the lab, you design and carry out experiments to determine norepinephrine\'s target. From your data, you generate one hypothesis about how norepinephrine might mediate a shift in neural information processing, like that which occurs when we \x26quot;pay attention\x26quot;. \x3cb\x3eAdvanced students really like this lab! \x3c/b\x3e\r\nHere, glutamate is an excitatory neurotransmitter acting through classic ionotropic receptors and norepinephrine, acts here as a \x26quot;metabotropic\x26quot; transmitter by binding to receptors coupled to second messengers that exert \x26quot;indirect\x26quot; long-term modulatory effects on the CA1 cell.\r\n\x3c/span\x3e\x3cbr/\x3e\n\x3cbr/\x3e\n\x3cstrong\x3eKey Concepts\x3c/strong\x3e: Experimental design; Neurotransmitter interactions; Neurotransmitters\x3cbr/\x3e\n\x3cstrong\x3eCourses\x3c/strong\x3e: Neurobiology\x3cbr/\x3e\n          \x3cbr/\x3e\x3ca href=\"/search_result_details/brief/96\" class=\"node_brief\"\x3eRead less\x3c/a\x3e        \x3cbr/\x3e  \x3c/span\x3e \x3c!-- description --\x3e\n" }